Cystic Fibrosis
Cystic Fibrosis
Cystic fibrosis, or CF, is a genetic disorder involving the lungs, pancreas, and other organs. The condition is caused by mutations in the CFTR gene. These mutations lead to the production of abnormally thick, sticky mucus that can block the lungs, pancreas, and other organs. CF is a lifelong disease usually detected in childhood. It requires ongoing treatment to manage symptoms and complications. Manipal Hospitals offers multidisciplinary care for patients with CF.
Treatments Available at
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Old Airport Road - Bengaluru
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Whitefield - Bengaluru
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Manipal Clinic - Brookefield - Bengaluru
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Jayanagar - Bengaluru
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Manipal Clinic - Jayanagar - Bengaluru
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Malleshwaram - Bengaluru
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Yeshwanthpur - Bengaluru
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Hebbal - Bengaluru
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Sarjapur Road - Bengaluru
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Varthur Road - Whitefield - Bengaluru
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Request a CallbackSymptoms of Cystic Fibrosis
CF symptoms vary but commonly include persistent cough with thick mucus, recurrent lung infections, wheezing, poor weight gain, and frequent respiratory illnesses. Patients may also experience digestive difficulties, greasy stools, or salty-tasting skin.
How We Diagnose Cystic Fibrosis
CF diagnosis includes a sweat chloride test that measures the amount of chloride (salt) in sweat. High chloride levels strongly suggest CF. Genetic testing may be used to detect mutations in the CFTR gene. Newborn screening tests are recommended to detect CF in infants. Diagnostic testing is then performed to confirm the diagnosis.
Treatment Options
CF treatment is mainly symptomatic and preventive. Treatments may include mucus-thinning drugs, airway clearance techniques, antibiotics to treat lung infections, and pancreatic enzyme replacement therapy. Nutritional support is critical to ensure adequate growth and health.
What to Expect
CF management at Manipal Hospitals requires long-term multidisciplinary care. This involves an experienced team of pulmonologists, gastroenterologists, nutritionists, and physiotherapists. Treatment is mainly focused on maintaining lung function, preventing infections, and supporting adequate nutrition.
Airway clearance forms an important part of CF treatment. These therapies help mobilise thick mucus from the lungs. This allows easier breathing and reduces the risk of respiratory infections. Bronchodilators, mucolytic agents, and inhaled antibiotics may be prescribed to improve airway function and control respiratory infections.
Doctors recommend pancreatic enzyme supplements for many people with CF to assist with nutrient absorption. They also provide nutritional guidance to support normal growth and weight maintenance. This may include a high-calorie diet and vitamin supplementation.
Routine monitoring helps doctors assess lung function, detect infections, and modify treatment when required. For some patients, specialised drugs called CFTR modulators help improve the function of the defective CFTR protein. Proper monitoring and appropriate treatment can help patients with CF lead active and fulfilling lives.
Consult our Experts
FAQs
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What results in CF?
CF causes involve inherited mutations in the CFTR gene, which regulates the movement of salt and water across cell membranes. These mutations result in the production of thick, sticky mucus that affects the lungs, pancreas, and other organs.
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Is CF an inherited condition?
Yes. CF is a disorder with autosomal recessive inheritance. A child develops this condition only if he or she inherits one altered CFTR gene from each parent. Individuals who carry a single altered gene usually do not develop any symptoms.
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Can CF affect digestion?
Yes. Thick, sticky mucus can block ducts in the pancreas and prevent digestive enzymes from reaching the intestines. This can lead to poor nutrient absorption, greasy stools, abdominal discomfort, and difficulty gaining weight.
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Is there any cure for CF?
There is no definitive cure for CF. However, advanced treatments can manage symptoms, reduce complications, and improve overall lung function. New therapies that target the underlying CFTR protein defect can significantly improve long-term outcomes.
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Can CF be detected before birth?
Yes. CF may sometimes be identified during pregnancy through prenatal genetic testing if both parents are known carriers of CFTR mutations. Diagnostic tests such as chorionic villus sampling or amniocentesis can confirm the condition.
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