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Dr. Lohith P

Associate Consultant - Robotic Surgical Gastroenterology and GI Onco Surgery

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Dr. Lohith P | Best Gastrointestinal & Robotic Surgeon in Yeshwanthpur | Manipal Hospitals
Reviewed by

Dr. Lohith P

Associate Consultant - Robotic Surgical Gastroenterology and GI Onco Surgery

Manipal Hospitals, Yeshwanthpur

From Heartburn to Cancer Risk: How Acid Reflux and Ulcers Affect Your Stomach Health

Reviewed by:

Dr. Lohith P

Posted On: Dec 01, 2025
blogs read 9 Min Read
From Heartburn to Cancer Risk: How Acid Reflux and Ulcers Affect Your Stomach Health

You’ve probably had heartburn after a heavy, spicy meal and shrugged it off as nothing. That happens. But when that burn becomes regular, when food feels like it’s getting stuck, or when stomach pain lingers, it’s time to pay attention. Acid reflux and GERD sit at the start of a pathway that, left unchecked, can progress to peptic ulcers or contribute to changes in the stomach lining. In some cases, chronic irritation and infection with H. pylori raise long-term risks, including stomach cancer.

In this blog a leading gastrointestinal surgeon unpacks the real connections between reflux, ulcers, and cancer. He explains what to watch for, how doctors make a diagnosis (including the role of endoscopy), and the practical steps you can take for prevention and early detection. The message is simple: small, persistent symptoms deserve expert attention. Catching problems early keeps treatment simpler and outcomes better.

 

What Exactly Is Acid Reflux And GERD?

Acid reflux happens when stomach acid flows back into the oesophagus, the tube that connects your mouth to your stomach. A little reflux is normal occasionally. The trouble begins when reflux happens often or causes damage. When symptoms are regular, or the oesophagus shows inflammation on testing, it's called GERD.

How does that damage occur? Your lower oesophageal sphincter (LES), a ring of muscle at the junction of the esophagus and stomach, normally prevents backflow. If the LES loosens or pressure patterns change, acid can rise up frequently. Over time, that acid wears the lining away and creates irritation. That’s why persistent acid reflux symptoms such as burning, regurgitation, or chronic cough should not be ignored.

How Peptic Ulcers Form: And Where H. Pylori Fits In

A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine (duodenum). For decades, we blamed stress and spicy food. Now we know that two causes matter most: persistent acid exposure and infection with H. pylori bacteria. Non-steroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are another common culprit.

When H. pylori burrows into the stomach lining, it weakens natural defences and increases acid-related damage. That combination is what often allows ulcers to form. Without treatment, ulcers may bleed or perforate, causing serious illness. Treating H. pylori and controlling acid are central to healing and preventing recurrence.

Is There A Real Link to Stomach Cancer?

Not every case of reflux or ulcer turns into cancer. But certain pathways do raise risk. Long-term, untreated H. pylori infection is a well-established risk factor for stomach cancer. Chronic inflammation from ongoing reflux or untreated ulcers can also cause changes in the stomach or oesophageal lining (for example, Barrett’s oesophagus), which increases the risk for malignancy over the years.

This is why prevention of stomach cancer becomes a realistic aim: detect and treat H. pylori, control acid reflux, monitor precancerous changes, and address persistent ulcer disease. Early detection matters. When precancerous conditions are identified and followed, doctors can intervene before cancer develops.
 

Symptoms and Warning Signs, You Shouldn’t Ignore

Most people wait until pain is severe before seeing a doctor. That delays diagnosis. Watch for these recurring or worrying signs:

  • Frequent acid reflux symptoms: burning behind the breastbone, sour taste, regurgitation.

  • Difficulty swallowing or a sensation of food sticking.

  • Persistent nausea, vomiting, or unexplained weight loss.

  • Upper abdominal pain that wakes you at night or doesn’t respond to ordinary antacids.

  • Black, tarry stools or visible blood in vomit (signs of bleeding ulcers).

  • New anemia without other explanation.

If you have any of these, book an appointment. These are signals that tell your digestive tract needs to be evaluated

How Doctors Diagnose the Problem: The Role of Endoscopy And Tests

A clear diagnosis starts with a careful history and targeted tests. Your doctor will ask about medicines (especially NSAIDs), alcohol, smoking, family history, and symptoms. Typical diagnostic steps include:

  • H. pylori testing — breath test, stool antigen, or blood antibody tests. Treating this infection prevents ulcers and lowers cancer risk.

  • Upper GI endoscopy (gastroscopy) — a camera passed through the mouth to view the oesophagus, stomach, and duodenum. This is the most important test for persistent symptoms. It finds ulcers, inflammation, and suspicious lesions. If needed, small biopsies are taken for lab analysis.

  • Imaging — ultrasound or CT if complications are suspected.

  • pH monitoring or manometry — these tests measure acid exposure and oesophageal function for difficult reflux cases.

When patients ask, “Does endoscopy hurt?” the answer is: it’s generally well tolerated with light sedation, and the diagnostic value is high. For those with alarm signs, endoscopy is the fastest route to an accurate diagnosis.

Medical Treatments: Control Acid, Eradicate Bugs, Heal Ulcers

Treatment depends on the diagnosis but follows a few core principles:

  • Acid suppression: Proton pump inhibitors (PPIs) are the backbone for healing reflux and ulcers. They reduce acid production and allow the lining to repair.

  • H. pylori eradication: A combination of antibiotics with acid suppression cures infection in most cases and markedly lowers long-term risk.

  • Protecting the stomach: For people who must take NSAIDs, co-prescription of PPIs or use of alternatives is standard.

  • Endoscopic therapy: For bleeding ulcers or suspicious lesions, therapeutic endoscopy can stop bleeding and obtain biopsies.

  • Surgery: Rarely required for ulcers now, but sometimes needed for complications (perforation) or severe, refractory reflux (anti-reflux procedures). Minimally invasive surgical approaches(Robotic and laparoscopic) are commonly used.

The aim is simple: stop the damage, treat the cause, and prevent recurrence.

Lifestyle Steps That Matter

Lifestyle changes may sound generic, but they work and complement medical care. Try these practical measures:

  • Reduce or avoid alcohol and smoking, both of which worsen reflux and delay ulcer healing.

  • Cut back on spicy or very fatty meals if they trigger your symptoms.

  • Eat smaller, regular meals; avoid late-night heavy dinners.

  • Stay upright for two hours after eating; gravity helps keep acid down.

  • Losing excess weight, even modest weight loss, lowers reflux frequency.

  • Avoid long-term NSAID use; use alternatives when possible and discuss gastroprotection with your doctor.

  • Maintain a balanced diet rich in vegetables and fibre; this supports gut health and recovery.

These changes won’t replace medical treatment when needed, but they make medicines and procedures more effective.

Monitoring and Follow-Up: When Surveillance Is Needed

If you have chronic GERD, long-standing ulcers, or a history of H. pylori, surveillance is sometimes advised. For example, Barrett’s oesophagus, a condition from chronic reflux where the oesophageal lining changes, often requires periodic endoscopy to watch for precancerous changes. People treated for H. pylori may need follow-up testing to confirm eradication.

Your care plan should be personalised. Some people need only a single course of treatment and symptom control. Others require long-term surveillance. That decision is based on age, family history, symptom severity, and findings on endoscopy.

When to See A Specialist: Don’t Delay If Symptoms Persist

If symptoms recur, if you have any of the warning signs listed earlier, see a surgical gastroenterologist. Early specialist input can prevent complications and offer minimally invasive solutions when appropriate.

Minimally invasive procedures, like Robotic or laparoscopic anti-reflux surgery, help people who don’t respond to medicine or who have anatomical problems such as a hiatal hernia. For peptic ulcer complications, timely surgical care can be lifesaving.

Prevention Of Stomach Cancer: What You Can Do Now

You can influence several modifiable risks for stomach cancer:

  • Test and treat H. pylori when indicated, especially in people with a family history or persistent ulcers.

  • Manage long-standing reflux and Barrett’s oesophagus under specialist care.

  • Avoid tobacco and limit alcohol.

  • Keep a healthy diet and maintain a healthy weight.

  • Follow up with endoscopy when your clinician recommends surveillance.

Early identification and management are the most practical strategies for the prevention of stomach cancer.

Conclusion

A burning sensation after a meal may be common, but repeated or worsening symptoms are not. Acid reflux, GERD, peptic ulcers, and H. pylori infection form a chain in which early links are easy to treat, and later links, including stomach cancer, are much harder. Catching problems early keeps treatment simpler and recovery faster.

If you’ve had recurring heartburn, unexplained upper abdominal pain, swallowing difficulties, or any of the red flags described here, plan to see a Surgical gastroenterologist in Manipal Hospital, Yeshwanthpur. Get the right test, the right treatment, and the peace of mind you deserve. Early action gives you the best outcome.

FAQ's

If heartburn happens more than twice weekly, wakes you at night, or is accompanied by trouble swallowing, weight loss, vomiting, or anaemia, see a doctor. Those signs suggest GERD complications or ulcers that need testing.
 

Yes. Eradicating H. pylori heals many ulcers and reduces recurrence. Over time, treating the infection also lowers the long-term risk associated with gastric inflammation and some stomach cancers.
 

Proton pump inhibitors are effective and generally safe when used appropriately. Long-term use should be reviewed by your doctor, with the lowest effective dose used and regular reassessment of the need for ongoing therapy.
 

No. Most peptic ulcers heal with medical therapy and H. pylori eradication. Surgery is reserved for complications such as perforation, uncontrolled bleeding, or obstruction.
 

The interval depends on findings. If you have Barrett’s oesophagus or other precancerous changes, your gastroenterologist will recommend a surveillance schedule. If tests are normal, follow-up is based on symptoms and risk factors.
 

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