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Dr. Shivaji Ramchandra Vibhute

Consultant - Laparoscopic, General, Colorectal Surgeon

Manipal Hospitals, Kharadi

Unexplained Weight Loss: What It Means for Your Health

Posted On: Sep 19, 2025
blogs read 5 Min Read
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Losing weight is often celebrated as a sign of discipline or healthy lifestyle changes. But what if you notice a drop in your weight without changing your diet or activity levels? This phenomenon, known as unexplained weight loss, can be a subtle signal from your body that something is off. While it may seem harmless, ignoring it could sometimes mean missing an underlying health concern.

At Manipal Hospital Kharadi, our internal medicine specialists frequently see patients experiencing unexpected weight loss. Understanding the causes, implications, and treatment options is key to maintaining your overall health.

 

What Is Unexplained Weight Loss?

Unexplained weight loss refers to a noticeable decrease in body weight without actively trying through diet, exercise, or lifestyle changes. Typically, losing more than 5% of your body weight over six to twelve months without explanation warrants medical attention. While some weight fluctuation is normal, sudden or significant loss can signal an underlying issue.

Common Causes of Unexplained Weight Loss

Weight loss without trying, but feeling otherwise fine, can be confusing. Here are some of the most common causes:

1. Metabolic Disorders

Conditions like hyperthyroidism increase metabolism, burning calories faster than normal. People may experience rapid weight loss despite eating normally, along with symptoms such as sweating, irritability, or tremors.

2. Digestive System Issues

Diseases affecting digestion, absorption, or nutrient intake, such as celiac disease, Crohn’s disease, or chronic pancreatitis, can cause unintentional weight loss. These conditions might be accompanied by digestive discomfort, bloating, or irregular bowel movements.

3. Chronic Infections

Persistent infections like tuberculosis, HIV, or endocarditis can lead to a gradual decrease in body weight. Often, these conditions also cause fatigue, fever, or night sweats, though sometimes weight loss is the first noticeable symptom.

4. Cancer

Certain cancers, especially those affecting the stomach, pancreas, or lungs, can cause unexplained weight loss. This happens due to changes in metabolism and the body’s increased energy demands to fight disease.

5. Mental Health Conditions

Stress, anxiety, and depression can also contribute to unintentional weight loss. These conditions may reduce appetite or affect eating habits, even if a person feels otherwise physically healthy.

6. Other Causes

Other possible reasons include diabetes, chronic kidney disease, and heart failure. Certain medications can also trigger weight loss as a side effect.

Unexplained Weight Loss in Females

Women may experience causes of weight loss due to various reasons such as hormonal fluctuations, pregnancy, or menopause. Thyroid disorders, polycystic ovary syndrome (PCOS), and reproductive system-related conditions can all contribute to unintentional weight changes.

Recognising these differences is crucial, and the Department of Internal Medicine at Manipal Hospitals Kharadi, Pune, ensure a thorough evaluation for female patients experiencing sudden weight changes.

When Weight Loss Occurs With No Other Symptoms

Sometimes, people notice unexplained weight loss with no other symptoms. While this may seem less alarming, it still requires a medical assessment. Hidden conditions like early-stage cancer, thyroid dysfunction, or nutrient malabsorption may not show obvious signs initially.

A prompt consultation with our top Specialist at the Manipal Hospitals, Kharadi, can lead to early detection, which significantly improves treatment outcomes.

How Is Unexplained Weight Loss Evaluated?

At Manipal Hospital Kharadi, a comprehensive evaluation is the first step to understanding sudden weight loss. This may include:

  • Medical History Review: Understanding lifestyle, diet, medications, and recent changes.

  • Physical Examination: Checking for signs of disease or malnutrition.

  • Laboratory Tests: Blood tests to evaluate thyroid, liver, and kidney function and blood sugar levels.

  • Imaging: Ultrasound, CT scans, or MRI to detect hidden abnormalities.

  • Specialised Tests: Endoscopy or biopsies if gastrointestinal or cancer-related issues are suspected.

Early assessment ensures that any underlying conditions are identified before they progress.

Treatment of Unexplained Weight Loss

The treatment for unexplained weight loss depends on the root cause. Common approaches include:

  • Addressing Underlying Conditions: Managing thyroid disorders, infections, diabetes, or cancers.

  • Nutritional Support: High-calorie diets, supplements, or meal planning to restore weight.

  • Lifestyle Adjustments: Stress management, physical activity modifications, and monitoring of eating habits.

  • Medication Review: Adjusting drugs that may contribute to weight loss.

Treatment is personalised, and the internal medicine team at Manipal Hospital Kharadi works closely with nutritionists, gastroenterologists, endocrinologists, and other specialists to provide holistic care.

Prevention and Monitoring

While not all cases of unexplained weight loss can be prevented, maintaining overall health can help reduce risk.

  • Regular medical checkups to detect early health issues.

  • Balanced nutrition with adequate calories and protein.

  • Stress management through mindfulness, exercise, or therapy.

  • Monitor weight and report sudden changes promptly.

Check Out More of Our Blogs: How to Stay Protected from Cold & Flu

Conclusion

Unexplained weight loss is more than just a number on the scale; it is your body signalling that something may be wrong. Early evaluation by qualified specialists, such as those at Manipal Hospital Kharadi, ensures that any underlying medical condition is addressed promptly. Whether the cause is hormonal, digestive, infectious, or psychological, a proactive approach can restore your health and prevent complications.

Don’t ignore sudden changes in your weight. Monitoring your body, staying aware of other subtle symptoms, and seeking expert care can make all the difference.

FAQ's

Unintentional weight loss of more than 5% of your body weight over six to twelve months is generally considered significant.

Yes, prolonged stress or anxiety can reduce appetite and disrupt metabolism, leading to weight loss.

Not always, but it can indicate conditions like thyroid problems, diabetes, infections, or cancer, so evaluation is important.

If weight drops noticeably over a few months without changes in diet or exercise, consult an internal medicine specialist promptly.

Yes. Adequate nutrition, stress management, and medical supervision can help restore a healthy weight and identify the underlying cause.

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