Diabetes Therapy with Glucose Biosensor Applications

Diabetes care centre in Bangalore

A biosensor is a type of detecting device that senses the presence of chemicals in living organisms. Here biological molecules like particular enzymes or antibodies are used by the biosensor to detect chemicals in the living organism. Because of their accuracy, biosensors are used extensively in healthcare screening procedures and subsequently therapies for various illnesses. They may be a one-time test kit application or a part of a device that monitors health parameters over a long period.

A glucose biosensor is a device that measures the level of blood glucose and thus helps in the therapy of diabetes. The different parts of a glucose biosensor include the following parts.

  • Determinant

This is the substance whose chemical constituents are detected by the biosensor. Here, the determinant is glucose within the bloodstream.

  • Bio Receptor

It is a highly specific reactant that is specific for the determinant. Here glucose is the determinant that is detected by the enzyme present within the test strip. The test strip is to be inserted into the glucometer. 

  • Sensor

This is the part that actually recognises the determinant and converts it into a signal that may be measured. Electrical signals are detected in glucometres. 

  • Display

This is the part where the sensed electrical signal is shown on a screen after being quantified. Here the glucometer displays the detected quantity of glucose on the display.

There are different types of glucose sensors that are available today. One type includes the discrete form that is the test strip form of the glucometer. The other type is the one that can be worn on the body and is a continuous glucometer. Both types are based on a similar detection method. Book an appointment at Manipal Hospitals today.

Most of the glucose metres or glucose monitors work on the principle where the bio receptor is an enzyme. The enzyme reacts with the sensor or the glucose if present in the blood and produces a positive result. Some types of enzymes normally employed in glucometer varieties are listed as follows.

  • Glucose dehydrogenase flavin adenine dinucleotide

  • Glucose oxidase

  • Glucose dehydrogenase pyrroloquinoline quinone

  • Glucose dehydrogenase nicotinamide adenine dinucleotide

Glucose metres are more commonly used blood glucose detecting devices and work on the principle where enzyme-coated testing strips are used. Since the blood is to be loaded onto the testing strip, one strip may be used only once. The enzyme on the strip detects the presence of glucose and transmits the signal to the glucose metre which then calculates the concentration of the glucose in the blood. The level of glucose is then displayed on the screen of the glucose metre. Visit our diabetes care hospital in Bangalore for treatment.

A Continuous Glucose Monitor (CGM) screens for glucose levels in the interstitial fluid or the intercellular fluid. There is a filament that is covered with glucose-specific enzymes that detects the presence of glucose in the fluid. The CGM thus monitors the levels of glucose in the body throughout the day. While the sensor is embedded in the skin of the person, there is a transmitter located above the skin that relays the detected information to the connected receiver. This transmitter may even be connected to a smartphone wirelessly to have access to the glucose records.

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