The blood cells are made in the bone marrow of humans. If malformed or less in number, these cells could not function correctly. This could be due to various diseases or conditions. In these cases, a bone marrow transplant (BMT) becomes valuable. In a BMT, unhealthy or abnormal blood-forming cells (stem cells) in the bone marrow are replaced with healthy ones. It is a non-surgical procedure as the new cells are injected into the bloodstream through an intravenous (IV) catheter or tube, similar to how blood or medicines are injected. Also known as hematopoietic stem cell transplant, this procedure is required for patients whose bone marrow stops working and does not produce enough healthy blood cells. BMT is usually done either after radiation and chemotherapy or both in children who need this procedure for whatever reason. It can be blood cancer (ALL, AML, JMML, CML, etc.), lymphoma (Hodgkin or Non-Hodgkin), aplastic anaemia, bone marrow failure syndromes (like Fanconi or Diamond Blackfan Anemia), primary immunodeficiency diseases (like SCID, WAS), hemoglobinopathy (like Thalassemia or Sickle Cells Disease), metabolic diseases like (Adrenoleukodystrophy, Hurler syndrome) or others.
Because a Transplant Is Never Just One Day
Organ failure rarely announces itself all at once. It's a gradual conversation between symptoms, tests, and decisions. Choosing the right transplant partner means choosing a team that's present for all of it:
The Before — Comprehensive evaluation, organ-matching, donor workup, and honest counselling on every option available, medical and surgical.
The During — Advanced surgical technique, robotic and minimally invasive options where applicable, and critical care protocols built around patient and donor safety.
The After — Structured recovery plans, immunosuppression management, and rehabilitation support for the recipient.
And Ever After — Lifelong follow-up, nutrition and lifestyle guidance, and continued monitoring for both recipient and living donor — because two lives deserve equal, ongoing care.
Depending on the source of stem cells, there are two types of bone marrow transplants:
Autologous transplant (cells sourced from the patient themself)
Allogeneic transplant (cells are sourced from a donor, related or unrelated)
When we don’t have a matched related or unrelated donor for an allogeneic bone marrow transplant, we do 50% HLA-matched bone marrow transplants, popularly called haploidentical BMT. At Manipal Hospitals, Delhi, we offer BMT procedures for both types. Consult with our team of bone marrow transplant specialists in Pune.
Treatment and Procedure
At Manipal Hospitals, Delhi, we have a team of proficient transplant physicians who provide excellent treatment and care for young patients who need a bone marrow transplant. We offer all types of bone marrow transplants:
When the stem cells for transplant come from the patient themself, it is called an autologous transplant. The stem cells are collected from the bone marrow or blood of the patient well before the transplant starts and then reused once chemo-immunotherapy (conditioning) for that transplant has been given. The autologous transplant helps by killing the cancer cells but retaining the body’s ability to produce the required blood cells and fight infections. Few experts call it high-dose chemotherapy followed by stem cell rescue.
When the stem cells for transplant come from a healthy donor (related or unrelated), it is called an allogeneic transplant. In cases of leukaemia or other malignancies, the new stem cells from a donor destroy the cancer cells and remain in the body throughout life, thereby treating cancer. The donor's blood proteins, human leukocyte antigens (HLA), must match with patients for a donation to be possible. Earlier, HLA was supposed to be 100% matching for a transplant possibility. Still, nowadays, in related donors (donors from the family), even if HLA is just 50% matched, we can do an allogeneic BMT, popularly called a haploidentical bone marrow transplant. This option is for those patients who cannot find a suitable donor (in the family or the registries); we offer haploidentical bone marrow transplants. These transplants can be T-replete (post-transplant cyclophosphamide) or T-deplete (TCR αβ and B depleted) bone marrow transplants, depending upon the disease and condition of the patient. In haploidentical BMT, the donor is usually a family member (sibling or either of the parent), and we very rarely need someone like a sibling of a parent or even grandparents. The option of a haploidentical bone marrow transplant almost always ensures that they can be given one if a patient needs an allogeneic transplant. With time, the results of haploidentical BMT have matured and are almost the same as that of other allogeneic transplants.
Umbilical Cord Blood Transplant
This is offered very rarely nowadays. In this procedure, umbilical cord blood is used to harvest stem cells for transplantation. The blood that remains in the umbilical cord after a baby is born is known as umbilical cord blood. Modern facilities allow the storage of umbilical cord cells and blood. They can be used for tiny babies or patients, particularly in metabolic diseases.
Manipal Hospitals, Delhi, offers the best bone marrow transplant services under the guidance of Dr. Satyendra Katewa. He is a Paediatric Hematology, Oncology & Bone Marrow Transplant consultant at Manipal Hospitals, Delhi. He is a pioneer in establishing haploidentical and more advanced allogeneic bone marrow transplants for the children of India. Visit our top bone marrow transplant hospital in Pune today for the best treatment.
Our range of facilities and services include but is not limited to:
Department of Hemato-pathology and Molecular Genetics
Department of transfusion medicine (Immunohematology), capable of T cells depletion procedures
Department of Infectious Diseases
Dedicated Pediatric Critical Care team
Specialized Pediatric Transplant Daycares with HEPA-filter facilities
Team of experienced experts, including doctors and nurses
Specially trained paramedical staff for pediatric patients
Diagnostic services
Varian HD linear accelerator
Ultra-modern PET-CT scan
CT scan
MRI scan
All pathological & microbiological investigations
Ten-colour flow cytometry to detect minimal residual disease of blood cancers and also in profiling of various other immune cells
Cytokine profiling
TNF-alpha
Supportive services
Emergency/ICU speciality
Multi-disciplinary support
Your specialist evaluates organ function through advanced diagnostics, clinical assessments, and medical history to determine if transplantation is the necessary path when medical management can no longer maintain safe organ function.
Manipal’s Beyond Transplant program is about supporting both the patient and the donor throughout the entire healthcare journey—long before and long after the surgery. Every enquiry is handled with speed, clarity, empathy, and precise clinical guidance to connect families with the appropriate transplant specialists.
Recovery begins with a structured hospital stay followed by lifelong follow-up care, specialized immunosuppressive medications to prevent organ rejection, and regular monitoring to ensure both the recipient and the new organ thrive.
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