Unlike blood donations, which can be given to the millions and millions of people who share the same blood type, stem cell donors are carefully matched to their recipients on a one-to-one basis.
The key to finding a good match is a set of molecules called Human Leukocyte Antigens (abbreviated as HLAs), which decorate the surface of peripheral blood stem cells and most other cells. It’s as if all of your cells share the same fingerprints. These “markers” distinguish your cells from potentially dangerous trespassers like viruses, bacteria, or cancer.
Individuals inherit their HLA antigens (tissue type) from their parents. Since this is the case, it makes sense that a ‘match’ for stem cell donation is more commonly found within a family group.
Individuals inherit their HLA antigens (tissue type) from their parents. Since this is the case, it makes sense that a ‘match’ for stem cell donation is more commonly found within a family group. To know more, visit the best organ transplant specialist in Vijayawada.
HLA genes are found on the short arm of chromosome 6 and every individual inherits two sets of antigens: one set from each parent. HLA antigen groups are divided into two major categories: class I and class II.
Every person harbors their own intricate set of HLA markers, and most of the donor’s markers have to be the same as the recipient’s to be deemed a match. There are so many possible combinations of these markers, however, that not everyone will find a match. The chances of a donor being matched to the patient are anywhere from 1 in 450 to 1 in 750,000 depending on the rarity of the individual’s HLA antigens. The more HLAs that are shared between donor and recipient, the better the match. The HLA system plays a major role in the graft versus host disease (GvHD) response.
1. Siblings first (Matched Sibling Donor)
Donors are initially sought among the patient’s siblings. Your sibling has a 1 in 4 (25%) chance of being a match. Sometimes they might be too old, or not healthy or just refuse to be a donor.
2. Matched unrelated donors
Stem cell registries search on behalf of thousands of patients in need of a lifesaving stem cell transplant. To facilitate matchmaking, they curate lists of potential donors that doctors can check when their patient needs a stem cell transplant. Every new registrant brings hope to those waiting.
DATRI Blood stem cell donor’s registry
Marrow Donor Registry (India)
DKMS BMST foundation India
Jeevan stem cell foundation
The Arjan Vir foundation
3. Alternative donors
Consultant - Hemato-Oncology And Bone Marrow Transplant
At the beginning of the pandemic, no evidence-based treatments were available for…
It depends on the severity of COVID 19, Most of the COVID 19 infected people are…
Unlike blood donations, which can be given to the millions and millions of people…