English

    Overview

  • Dr. Darshan Krishnappa is an exceptionally accomplished Cardiac Electrophysiologist and Cardiologist at Old Airport Road with over 16+ years of extensive clinical experience in the management of complex cardiac rhythm disorders, advanced catheter ablation, and device-based therapies. He is currently practising as a Lead Consultant – Cardiac Electrophysiology at Manipal Hospital Old Airport Road, Bangalore. Dr. Krishnappa possesses highly specialised expertise in heart rhythm device therapy (including defibrillators and cardiac resynchronisation therapy), complex arrhythmia mapping, sudden cardiac arrest prevention, and lead extractions. His integration of advanced ablation techniques with cutting-edge medical device technology has established him among the best cardiac electrophysiologists in Old Airport Road for precision heart rhythm care.

  • Dr. Krishnappa completed his foundational MBBS at the Kempegowda Institute of Medical Sciences (KIMS), Bengaluru. He then undertook highly competitive postgraduate training in Internal Medicine (MD) at the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi, providing him a rigorous grounding in critical care and complex multisystem diseases. He subsequently pursued super-speciality training in Cardiology (DM) at the leading Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, gaining high-volume exposure to advanced interventional cardiology. To further subspecialise, he completed a Clinical Cardiac Electrophysiology Fellowship at the University of Minnesota, Minneapolis, USA, while simultaneously serving as an Innovation Fellow at the Earl E. Bakken Medical Devices Centre.

  • At Manipal Hospital Old Airport Road, Dr. Darshan Krishnappa performs a broad spectrum of advanced cardiac electrophysiology procedures with an emphasis on physiological precision and long-term rhythm stability. His clinical portfolio features complex arrhythmia management, including specialised catheter ablations for atrial fibrillation (AF) and ventricular arrhythmias. He is highly proficient in handling challenging heart rhythm issues in patients with congenital heart disease, inflammatory cardiomyopathy (sarcoidosis), cardiac amyloidosis, and syncope. (Note: The hospital's portal mistakenly auto-categorised him under a completely separate speciality in one line, but his practice is strictly dedicated to advanced cardiovascular rhythm care.) His clinical mastery positions him among the best heart specialists and cardiologists in Old Airport Road, Bangalore.

  • Dr. Krishnappa’s technical expertise is uniquely augmented by his contributions to translational medicine and biomedical engineering. Further reflecting his leadership in the field, he serves as India’s Representative to the Asia Pacific Heart Rhythm Society (APHRS) EP Committee, actively shaping regional academic collaboration and advancement in cardiac electrophysiology across the Asia-Pacific region. In recognition of his professional excellence and academic contributions, he was elected a Fellow of the American College of Cardiology (FACC).

  • Dr. Darshan Krishnappa is deeply involved in cardiovascular research, boasting an extensive publication record in elite, peer-reviewed global journals such as Circulation, Journal of the American Heart Association, Journal of Cardiovascular Electrophysiology, and Nature Scientific Reports. His landmark research contributions include risk stratification in atrial fibrillation using the ARIC cohort data, substrate characterisation for scar-mediated ventricular tachycardia, and investigating subclinical isolated cardiac amyloidosis in elderly patients. He is an active member of the Heart Rhythm Society (HRS), European Heart Rhythm Association (EHRA), and the Indian Heart Rhythm Society (IHRS). Fluent in Kannada, English, Hindi, and Telugu, he uses his multilingual capabilities to deliver truly personalised, patient-centric care.

    • Field of Expertise

  • Heart Rhythm device therapy including Defibrillators and resynchronisation therapy and lead extraction
  • Sudden cardiac arrest - prevention and management
  • Complex arrhythmia management including atrial fibrillation and ventricular arrhythmias
  • Arrhythmias in patients with congenital heart disease
  • Inflammatory cardiomyopathy (sarcoidosis) and amyloidosis
  • Syncope
  • Heart failure

    • Fellowship & Membership

  • Heart Rhythm Society
  • Amerian College of Cardiology
  • European Heart Rhythm Association
  • Indian Heart Rhythm Society

    • Languages Spoken

  • Kannada
  • English
  • Hindi
  • Telugu

    • Talks & Publications

  • Krishnappa D, Wang W, Rooney MR, Norby FL, Oldenburg NC, Soliman EZ, Alonso A, O-Uchi J, Dudley SC Jr, Lutsey PL, Chen LY. Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study. Int J Cardiol. 2021 Jun 1;332:70-77. doi: 10.1016/j.ijcard.2021.02.083.
  • Garg PK, Norby FL, Wang W, Krishnappa D, Soliman EZ, Lutsey PL, Selvin E, Ballantyne CM, Alonso A, Chen LY. Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2021 Nov 1;158:45-52.
  • Kohno R, Cannom DS, Olshansky B, Xi SC, Krishnappa D, Adkisson WO, Norby FL, Fedorowski A, Benditt DG. Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association. J Am Heart Assoc. 2021 Sep 7;10(17):e021002
  • Yash Paul Sharma, Kewal Kanabar, Krishna Santosh, Ganesh Kasinadhuni, Darshan Krishnappa. Role of N-terminal pro-B-type natriuretic peptide in the prediction of outcomes in ST-elevation myocardial infarction complicated by cardiogenic shock. Indian Heart Journal. Article in press
  • Hegde A, Masthi R, Krishnappa D. Hyperlocal Postcode Based Crowdsourced Surveillance Systems in the COVID-19 Pandemic Response. Front Public Health. 2020 Jun 9;8:286
  • Abhiram G Ashwathanarayana, Manphool Singhal, Swayamjeet Satapathy, Ashwani Sood, Bhagwant Rai Mittal, Rohit Manoj Kumar, Madan Parmar, Darshan Krishnappa, Nivedita Rana. 18 F-NaF PET uptake characteristics of coronary artery culprit lesions in a cohort of patients of acute coronary syndrome with ST-elevation myocardial infarction and chronic stable angina: A hybrid fluoride PET/CTCA study. J Nucl Cardiol 2020 Jul 27. Online Ahead of print.
  • Kewal Kanabar, Dinakar Bootla, Navjyot Kaur, C.R.Pruthvi, Darshan Krishnappa, Krishna Santosh, Vivek Guleria, Manoj Kumar Rohit. Outcomes of transcatheter closure of patent ductus arteriosus with the off-label use of large occluders (≥16 mm). Indian Heart Journal. March–April 2020; 72(4): 107-112
  • David G. Benditt , J. Gert van Dijk , Darshan Krishnappa , Wayne O. Adkisson and Scott Sakaguchi. Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults. Frontiers in Cardiovascular Medicine. 2020 May.
  • Darshan Krishnappa, Baris Akdemir, Teerapat Nantsupawat, Balaji Krishnan, Ilknur Can, Selcuk Adabag, Jian-Ming Li, Venkatakrishna N.Tholakanahalli. QTc dispersion as a novel marker in identifying patients requiring an epicardial approach for ablation of scar mediated ventricular tachycardia. Indian Pacing and Electrophysiology Journal. July-August 2020; 20(4): 141-146..
  • Arianne Clare Agdamag, Darshan Krishnappa, David Benditt. ST-Segment Changes After Loss of Consciousness. Circulation. 2020 Jan 7;141(1):80-82.
  • Krishnappa D, Dykoski R, Can I, Mbai M, Anand IS, Florea V, Chandrashekar YS, Li JM, Tholakanahalli VN. Atrial Fibrillation in the Elderly: The Role of Sub-Clinical Isolated Cardiac Amyloidosis. Scientific Reports (Nature) 2019 Nov 12;9(1):16584. PMID:31719596
  • Manojkumar Rohit, Krishnappa D. Incidence and predictors of super-response to cardiac resynchronization therapy. Indian Heart Journal. 2019 Jul - Aug;71(4):334-337.
  • Yash Paul Sharma, Darshan Krishnappa, Kewal Kanabar,Naga Ganesh Kumar Kasinadhuni, Rakesh Sharma, Kamal Kishore,Saurabh Mehrotra, Krishna Santosh Vemuri, Ankur Gupta, Prashant Panda. Clinical Characteristics and Outcome in Patients with a Delayed Presentation after STEMI and Complicated by Cardiogenic Shock. Indian Heart Journal. 2019 Sept – Oct.; 71(5): 387-393.
  • Teerapat Nantsupawat, Darshan Krishnappa, David Benditt. Sinus Arrest: A Rare Observation During Radiofrequency Ablation Along the Coronary Sinus Roof. Annals of Noninvasive Electrocardiography. Article in press
  • Krishnappa D, Sharma SK, Singh AD, Sinha S, Ammini AC, Soneja M. Impact of tuberculosis on glycaemic status: A neglected association. Indian J Med Res. 2019 Mar;149(3):384-388. PMID:31249204
  • Krishnappa D, Scott Sakaguchi, Ganesh Kasinadhuni, Venkatakrishna N Tholakanahalli. An unyielding valve leading to venous spasm during pacemaker implantation: a case report. Eur Heart J Case Rep. Article in press.
  • Vijayvergiya R, Kanabar K, Krishnappa D, Kasinadhuni G, Sharma A, Akasaka T. Optical coherence tomography in varying aetiologies of renal artery stenosis: a case series. Eur Heart J Case Rep. 2019 Jun 1;3(2). PMID: 31449625
  • Krishnappa D, Naganur S, Palanisamy D, Kasinadhuni G. Cardiac mucormycosis: a case report. Eur Heart J Case Rep. 2019 Sep 1;3(3). PMID: 31436824
  • Kasinadhuni G, Vijayvergiya R, Krishnappa D, Kanabar K, Yegurla J and Bhalla. Herb Induced Aconite Poisoning and Bidirectional Ventricular Tachycardia. Adv Clin Toxicol 2019, 4(3): 000161.
  • Kasinadhuni G, Sethi J, Krishnappa D, Sharma YP. A rare cause of ascites in arenal transplant recipient. BMJ Case Rep. 2018 Sep 18;2018. PMID: 30232075
  • Girish B, Gainder S, Saha SC, Krishnappa D. Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. J Obstet Gynaecol India. 2018 Feb;68(1):70-72. PMID: 29391679
  • Rohit M, Krishnappa D, Selvaraj RJ. Wide to narrow complex tachycardia: What is the diagnosis? J Cardiovasc Electrophysiol. 2018 Mar;29(3):487-488. PMID: 29319207
  • Kumar A, Jain DC, Gupta D, Satyanarayana S, Kumar AM, Chadha SS, Wilson N, Nagaraja SB, Shah AN, Naik B, Yoele D, Syed IF, Achanta S, Sharma SK, Soneja M, Krishnappa D, Prakash BC, Ravish S, Ranganath TS, Chauhan MC, Dave PV, Narayanaswamy MV, Suryakanth M, Bhist A, Sinha UC, Dayal R, Tekumalla RR, Nair S, Kumari AK, Subramonianpillai J, Jali MV, Mahishale VK, Hiremath MB, Khanna A, Lohiya S, Chaudhry A, Shaw N, Varadarajan S, Kapur A, Zachariah R, Harries AD. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health. 2013 May;18(5):636-45. PMID: 23458555
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Prashant Panda, Sandeep S. Rana, Ashim Dass. Cardiac myxoma of mitral valve: An uncommon presentation. Indian Heart Journal Cardiovascular Case Reports. May–September 2018;2(2):77-78.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ankush Gupta, Sarbpreet Singh, Ashish Sharma.Primary stenting of occluded innominate vein in a case of dialysis fistula malfunction- a 3.5-years follow-up. Indian Heart Journal Cardiovascular Case Reports. May–September 2018; 2(2):114-116.
  • Rajesh Vijayvergiya, Ganesh Kasinadhuni, Darshan Krishnappa, Ankush Gupta. Assessment of myocardial bridge by fractional flow reserve and optical coherence tomography in acute myocardial infarction. Indian Heart Journal Cardiovascular Case Reports. October-December 2017;1(3):114-116.
  • Rajesh Vijayvergiya, Ankush Gupta, Ganesh Kasinadhuni, Darshan Krishnappa, Prashant Panda. Intravascular ultrasound supported percutaneous coronary intervention of a large diameter right coronary artery. Indian Heart Journal Cardiovascular Case Reports. May-September 2018; 2(2): 106-107.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Ankush Gupta, Prashant Panda, Kumar J. Ratheesh.Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer. Indian Heart Journal Cardiovascular Case Reports. January-April 2018; 2(2):6-8.
  • Faint on standing from sitting or lying down? Know about Postural Hypotension - Dr. Darshan, Consultant – Cardiac Electrophysiology, Manipal Hospitals, Dr. Deepak P, Consultant – Cardiac Electrophysiology, Manipal Ho.Click Here

    Fellowship & Membership

  • Heart Rhythm Society
  • Amerian College of Cardiology
  • European Heart Rhythm Association
  • Indian Heart Rhythm Society

    • Overview

  • Dr. Darshan Krishnappa is an exceptionally accomplished Cardiac Electrophysiologist and Cardiologist at Old Airport Road with over 16+ years of extensive clinical experience in the management of complex cardiac rhythm disorders, advanced catheter ablation, and device-based therapies. He is currently practising as a Lead Consultant – Cardiac Electrophysiology at Manipal Hospital Old Airport Road, Bangalore. Dr. Krishnappa possesses highly specialised expertise in heart rhythm device therapy (including defibrillators and cardiac resynchronisation therapy), complex arrhythmia mapping, sudden cardiac arrest prevention, and lead extractions. His integration of advanced ablation techniques with cutting-edge medical device technology has established him among the best cardiac electrophysiologists in Old Airport Road for precision heart rhythm care.

  • Dr. Krishnappa completed his foundational MBBS at the Kempegowda Institute of Medical Sciences (KIMS), Bengaluru. He then undertook highly competitive postgraduate training in Internal Medicine (MD) at the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi, providing him a rigorous grounding in critical care and complex multisystem diseases. He subsequently pursued super-speciality training in Cardiology (DM) at the leading Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, gaining high-volume exposure to advanced interventional cardiology. To further subspecialise, he completed a Clinical Cardiac Electrophysiology Fellowship at the University of Minnesota, Minneapolis, USA, while simultaneously serving as an Innovation Fellow at the Earl E. Bakken Medical Devices Centre.

  • At Manipal Hospital Old Airport Road, Dr. Darshan Krishnappa performs a broad spectrum of advanced cardiac electrophysiology procedures with an emphasis on physiological precision and long-term rhythm stability. His clinical portfolio features complex arrhythmia management, including specialised catheter ablations for atrial fibrillation (AF) and ventricular arrhythmias. He is highly proficient in handling challenging heart rhythm issues in patients with congenital heart disease, inflammatory cardiomyopathy (sarcoidosis), cardiac amyloidosis, and syncope. (Note: The hospital's portal mistakenly auto-categorised him under a completely separate speciality in one line, but his practice is strictly dedicated to advanced cardiovascular rhythm care.) His clinical mastery positions him among the best heart specialists and cardiologists in Old Airport Road, Bangalore.

  • Dr. Krishnappa’s technical expertise is uniquely augmented by his contributions to translational medicine and biomedical engineering. Further reflecting his leadership in the field, he serves as India’s Representative to the Asia Pacific Heart Rhythm Society (APHRS) EP Committee, actively shaping regional academic collaboration and advancement in cardiac electrophysiology across the Asia-Pacific region. In recognition of his professional excellence and academic contributions, he was elected a Fellow of the American College of Cardiology (FACC).

  • Dr. Darshan Krishnappa is deeply involved in cardiovascular research, boasting an extensive publication record in elite, peer-reviewed global journals such as Circulation, Journal of the American Heart Association, Journal of Cardiovascular Electrophysiology, and Nature Scientific Reports. His landmark research contributions include risk stratification in atrial fibrillation using the ARIC cohort data, substrate characterisation for scar-mediated ventricular tachycardia, and investigating subclinical isolated cardiac amyloidosis in elderly patients. He is an active member of the Heart Rhythm Society (HRS), European Heart Rhythm Association (EHRA), and the Indian Heart Rhythm Society (IHRS). Fluent in Kannada, English, Hindi, and Telugu, he uses his multilingual capabilities to deliver truly personalised, patient-centric care.

    • Field of Expertise

  • Heart Rhythm device therapy including Defibrillators and resynchronisation therapy and lead extraction
  • Sudden cardiac arrest - prevention and management
  • Complex arrhythmia management including atrial fibrillation and ventricular arrhythmias
  • Arrhythmias in patients with congenital heart disease
  • Inflammatory cardiomyopathy (sarcoidosis) and amyloidosis
  • Syncope
  • Heart failure

    • Languages Spoken

  • Kannada
  • English
  • Hindi
  • Telugu

    • Talks & Publications

  • Krishnappa D, Wang W, Rooney MR, Norby FL, Oldenburg NC, Soliman EZ, Alonso A, O-Uchi J, Dudley SC Jr, Lutsey PL, Chen LY. Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study. Int J Cardiol. 2021 Jun 1;332:70-77. doi: 10.1016/j.ijcard.2021.02.083.
  • Garg PK, Norby FL, Wang W, Krishnappa D, Soliman EZ, Lutsey PL, Selvin E, Ballantyne CM, Alonso A, Chen LY. Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2021 Nov 1;158:45-52.
  • Kohno R, Cannom DS, Olshansky B, Xi SC, Krishnappa D, Adkisson WO, Norby FL, Fedorowski A, Benditt DG. Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association. J Am Heart Assoc. 2021 Sep 7;10(17):e021002
  • Yash Paul Sharma, Kewal Kanabar, Krishna Santosh, Ganesh Kasinadhuni, Darshan Krishnappa. Role of N-terminal pro-B-type natriuretic peptide in the prediction of outcomes in ST-elevation myocardial infarction complicated by cardiogenic shock. Indian Heart Journal. Article in press
  • Hegde A, Masthi R, Krishnappa D. Hyperlocal Postcode Based Crowdsourced Surveillance Systems in the COVID-19 Pandemic Response. Front Public Health. 2020 Jun 9;8:286
  • Abhiram G Ashwathanarayana, Manphool Singhal, Swayamjeet Satapathy, Ashwani Sood, Bhagwant Rai Mittal, Rohit Manoj Kumar, Madan Parmar, Darshan Krishnappa, Nivedita Rana. 18 F-NaF PET uptake characteristics of coronary artery culprit lesions in a cohort of patients of acute coronary syndrome with ST-elevation myocardial infarction and chronic stable angina: A hybrid fluoride PET/CTCA study. J Nucl Cardiol 2020 Jul 27. Online Ahead of print.
  • Kewal Kanabar, Dinakar Bootla, Navjyot Kaur, C.R.Pruthvi, Darshan Krishnappa, Krishna Santosh, Vivek Guleria, Manoj Kumar Rohit. Outcomes of transcatheter closure of patent ductus arteriosus with the off-label use of large occluders (≥16 mm). Indian Heart Journal. March–April 2020; 72(4): 107-112
  • David G. Benditt , J. Gert van Dijk , Darshan Krishnappa , Wayne O. Adkisson and Scott Sakaguchi. Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults. Frontiers in Cardiovascular Medicine. 2020 May.
  • Darshan Krishnappa, Baris Akdemir, Teerapat Nantsupawat, Balaji Krishnan, Ilknur Can, Selcuk Adabag, Jian-Ming Li, Venkatakrishna N.Tholakanahalli. QTc dispersion as a novel marker in identifying patients requiring an epicardial approach for ablation of scar mediated ventricular tachycardia. Indian Pacing and Electrophysiology Journal. July-August 2020; 20(4): 141-146..
  • Arianne Clare Agdamag, Darshan Krishnappa, David Benditt. ST-Segment Changes After Loss of Consciousness. Circulation. 2020 Jan 7;141(1):80-82.
  • Krishnappa D, Dykoski R, Can I, Mbai M, Anand IS, Florea V, Chandrashekar YS, Li JM, Tholakanahalli VN. Atrial Fibrillation in the Elderly: The Role of Sub-Clinical Isolated Cardiac Amyloidosis. Scientific Reports (Nature) 2019 Nov 12;9(1):16584. PMID:31719596
  • Manojkumar Rohit, Krishnappa D. Incidence and predictors of super-response to cardiac resynchronization therapy. Indian Heart Journal. 2019 Jul - Aug;71(4):334-337.
  • Yash Paul Sharma, Darshan Krishnappa, Kewal Kanabar,Naga Ganesh Kumar Kasinadhuni, Rakesh Sharma, Kamal Kishore,Saurabh Mehrotra, Krishna Santosh Vemuri, Ankur Gupta, Prashant Panda. Clinical Characteristics and Outcome in Patients with a Delayed Presentation after STEMI and Complicated by Cardiogenic Shock. Indian Heart Journal. 2019 Sept – Oct.; 71(5): 387-393.
  • Teerapat Nantsupawat, Darshan Krishnappa, David Benditt. Sinus Arrest: A Rare Observation During Radiofrequency Ablation Along the Coronary Sinus Roof. Annals of Noninvasive Electrocardiography. Article in press
  • Krishnappa D, Sharma SK, Singh AD, Sinha S, Ammini AC, Soneja M. Impact of tuberculosis on glycaemic status: A neglected association. Indian J Med Res. 2019 Mar;149(3):384-388. PMID:31249204
  • Krishnappa D, Scott Sakaguchi, Ganesh Kasinadhuni, Venkatakrishna N Tholakanahalli. An unyielding valve leading to venous spasm during pacemaker implantation: a case report. Eur Heart J Case Rep. Article in press.
  • Vijayvergiya R, Kanabar K, Krishnappa D, Kasinadhuni G, Sharma A, Akasaka T. Optical coherence tomography in varying aetiologies of renal artery stenosis: a case series. Eur Heart J Case Rep. 2019 Jun 1;3(2). PMID: 31449625
  • Krishnappa D, Naganur S, Palanisamy D, Kasinadhuni G. Cardiac mucormycosis: a case report. Eur Heart J Case Rep. 2019 Sep 1;3(3). PMID: 31436824
  • Kasinadhuni G, Vijayvergiya R, Krishnappa D, Kanabar K, Yegurla J and Bhalla. Herb Induced Aconite Poisoning and Bidirectional Ventricular Tachycardia. Adv Clin Toxicol 2019, 4(3): 000161.
  • Kasinadhuni G, Sethi J, Krishnappa D, Sharma YP. A rare cause of ascites in arenal transplant recipient. BMJ Case Rep. 2018 Sep 18;2018. PMID: 30232075
  • Girish B, Gainder S, Saha SC, Krishnappa D. Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. J Obstet Gynaecol India. 2018 Feb;68(1):70-72. PMID: 29391679
  • Rohit M, Krishnappa D, Selvaraj RJ. Wide to narrow complex tachycardia: What is the diagnosis? J Cardiovasc Electrophysiol. 2018 Mar;29(3):487-488. PMID: 29319207
  • Kumar A, Jain DC, Gupta D, Satyanarayana S, Kumar AM, Chadha SS, Wilson N, Nagaraja SB, Shah AN, Naik B, Yoele D, Syed IF, Achanta S, Sharma SK, Soneja M, Krishnappa D, Prakash BC, Ravish S, Ranganath TS, Chauhan MC, Dave PV, Narayanaswamy MV, Suryakanth M, Bhist A, Sinha UC, Dayal R, Tekumalla RR, Nair S, Kumari AK, Subramonianpillai J, Jali MV, Mahishale VK, Hiremath MB, Khanna A, Lohiya S, Chaudhry A, Shaw N, Varadarajan S, Kapur A, Zachariah R, Harries AD. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health. 2013 May;18(5):636-45. PMID: 23458555
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Prashant Panda, Sandeep S. Rana, Ashim Dass. Cardiac myxoma of mitral valve: An uncommon presentation. Indian Heart Journal Cardiovascular Case Reports. May–September 2018;2(2):77-78.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ankush Gupta, Sarbpreet Singh, Ashish Sharma.Primary stenting of occluded innominate vein in a case of dialysis fistula malfunction- a 3.5-years follow-up. Indian Heart Journal Cardiovascular Case Reports. May–September 2018; 2(2):114-116.
  • Rajesh Vijayvergiya, Ganesh Kasinadhuni, Darshan Krishnappa, Ankush Gupta. Assessment of myocardial bridge by fractional flow reserve and optical coherence tomography in acute myocardial infarction. Indian Heart Journal Cardiovascular Case Reports. October-December 2017;1(3):114-116.
  • Rajesh Vijayvergiya, Ankush Gupta, Ganesh Kasinadhuni, Darshan Krishnappa, Prashant Panda. Intravascular ultrasound supported percutaneous coronary intervention of a large diameter right coronary artery. Indian Heart Journal Cardiovascular Case Reports. May-September 2018; 2(2): 106-107.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Ankush Gupta, Prashant Panda, Kumar J. Ratheesh.Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer. Indian Heart Journal Cardiovascular Case Reports. January-April 2018; 2(2):6-8.
  • Faint on standing from sitting or lying down? Know about Postural Hypotension - Dr. Darshan, Consultant – Cardiac Electrophysiology, Manipal Hospitals, Dr. Deepak P, Consultant – Cardiac Electrophysiology, Manipal Ho.Click Here

    Languages Spoken

  • Kannada
  • English
  • Hindi
  • Telugu

    • Overview

  • Dr. Darshan Krishnappa is an exceptionally accomplished Cardiac Electrophysiologist and Cardiologist at Old Airport Road with over 16+ years of extensive clinical experience in the management of complex cardiac rhythm disorders, advanced catheter ablation, and device-based therapies. He is currently practising as a Lead Consultant – Cardiac Electrophysiology at Manipal Hospital Old Airport Road, Bangalore. Dr. Krishnappa possesses highly specialised expertise in heart rhythm device therapy (including defibrillators and cardiac resynchronisation therapy), complex arrhythmia mapping, sudden cardiac arrest prevention, and lead extractions. His integration of advanced ablation techniques with cutting-edge medical device technology has established him among the best cardiac electrophysiologists in Old Airport Road for precision heart rhythm care.

  • Dr. Krishnappa completed his foundational MBBS at the Kempegowda Institute of Medical Sciences (KIMS), Bengaluru. He then undertook highly competitive postgraduate training in Internal Medicine (MD) at the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi, providing him a rigorous grounding in critical care and complex multisystem diseases. He subsequently pursued super-speciality training in Cardiology (DM) at the leading Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, gaining high-volume exposure to advanced interventional cardiology. To further subspecialise, he completed a Clinical Cardiac Electrophysiology Fellowship at the University of Minnesota, Minneapolis, USA, while simultaneously serving as an Innovation Fellow at the Earl E. Bakken Medical Devices Centre.

  • At Manipal Hospital Old Airport Road, Dr. Darshan Krishnappa performs a broad spectrum of advanced cardiac electrophysiology procedures with an emphasis on physiological precision and long-term rhythm stability. His clinical portfolio features complex arrhythmia management, including specialised catheter ablations for atrial fibrillation (AF) and ventricular arrhythmias. He is highly proficient in handling challenging heart rhythm issues in patients with congenital heart disease, inflammatory cardiomyopathy (sarcoidosis), cardiac amyloidosis, and syncope. (Note: The hospital's portal mistakenly auto-categorised him under a completely separate speciality in one line, but his practice is strictly dedicated to advanced cardiovascular rhythm care.) His clinical mastery positions him among the best heart specialists and cardiologists in Old Airport Road, Bangalore.

  • Dr. Krishnappa’s technical expertise is uniquely augmented by his contributions to translational medicine and biomedical engineering. Further reflecting his leadership in the field, he serves as India’s Representative to the Asia Pacific Heart Rhythm Society (APHRS) EP Committee, actively shaping regional academic collaboration and advancement in cardiac electrophysiology across the Asia-Pacific region. In recognition of his professional excellence and academic contributions, he was elected a Fellow of the American College of Cardiology (FACC).

  • Dr. Darshan Krishnappa is deeply involved in cardiovascular research, boasting an extensive publication record in elite, peer-reviewed global journals such as Circulation, Journal of the American Heart Association, Journal of Cardiovascular Electrophysiology, and Nature Scientific Reports. His landmark research contributions include risk stratification in atrial fibrillation using the ARIC cohort data, substrate characterisation for scar-mediated ventricular tachycardia, and investigating subclinical isolated cardiac amyloidosis in elderly patients. He is an active member of the Heart Rhythm Society (HRS), European Heart Rhythm Association (EHRA), and the Indian Heart Rhythm Society (IHRS). Fluent in Kannada, English, Hindi, and Telugu, he uses his multilingual capabilities to deliver truly personalised, patient-centric care.

    • Fellowship & Membership

  • Heart Rhythm Society
  • Amerian College of Cardiology
  • European Heart Rhythm Association
  • Indian Heart Rhythm Society

    • Field of Expertise

  • Heart Rhythm device therapy including Defibrillators and resynchronisation therapy and lead extraction
  • Sudden cardiac arrest - prevention and management
  • Complex arrhythmia management including atrial fibrillation and ventricular arrhythmias
  • Arrhythmias in patients with congenital heart disease
  • Inflammatory cardiomyopathy (sarcoidosis) and amyloidosis
  • Syncope
  • Heart failure

    • Talks & Publications

  • Krishnappa D, Wang W, Rooney MR, Norby FL, Oldenburg NC, Soliman EZ, Alonso A, O-Uchi J, Dudley SC Jr, Lutsey PL, Chen LY. Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study. Int J Cardiol. 2021 Jun 1;332:70-77. doi: 10.1016/j.ijcard.2021.02.083.
  • Garg PK, Norby FL, Wang W, Krishnappa D, Soliman EZ, Lutsey PL, Selvin E, Ballantyne CM, Alonso A, Chen LY. Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2021 Nov 1;158:45-52.
  • Kohno R, Cannom DS, Olshansky B, Xi SC, Krishnappa D, Adkisson WO, Norby FL, Fedorowski A, Benditt DG. Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association. J Am Heart Assoc. 2021 Sep 7;10(17):e021002
  • Yash Paul Sharma, Kewal Kanabar, Krishna Santosh, Ganesh Kasinadhuni, Darshan Krishnappa. Role of N-terminal pro-B-type natriuretic peptide in the prediction of outcomes in ST-elevation myocardial infarction complicated by cardiogenic shock. Indian Heart Journal. Article in press
  • Hegde A, Masthi R, Krishnappa D. Hyperlocal Postcode Based Crowdsourced Surveillance Systems in the COVID-19 Pandemic Response. Front Public Health. 2020 Jun 9;8:286
  • Abhiram G Ashwathanarayana, Manphool Singhal, Swayamjeet Satapathy, Ashwani Sood, Bhagwant Rai Mittal, Rohit Manoj Kumar, Madan Parmar, Darshan Krishnappa, Nivedita Rana. 18 F-NaF PET uptake characteristics of coronary artery culprit lesions in a cohort of patients of acute coronary syndrome with ST-elevation myocardial infarction and chronic stable angina: A hybrid fluoride PET/CTCA study. J Nucl Cardiol 2020 Jul 27. Online Ahead of print.
  • Kewal Kanabar, Dinakar Bootla, Navjyot Kaur, C.R.Pruthvi, Darshan Krishnappa, Krishna Santosh, Vivek Guleria, Manoj Kumar Rohit. Outcomes of transcatheter closure of patent ductus arteriosus with the off-label use of large occluders (≥16 mm). Indian Heart Journal. March–April 2020; 72(4): 107-112
  • David G. Benditt , J. Gert van Dijk , Darshan Krishnappa , Wayne O. Adkisson and Scott Sakaguchi. Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults. Frontiers in Cardiovascular Medicine. 2020 May.
  • Darshan Krishnappa, Baris Akdemir, Teerapat Nantsupawat, Balaji Krishnan, Ilknur Can, Selcuk Adabag, Jian-Ming Li, Venkatakrishna N.Tholakanahalli. QTc dispersion as a novel marker in identifying patients requiring an epicardial approach for ablation of scar mediated ventricular tachycardia. Indian Pacing and Electrophysiology Journal. July-August 2020; 20(4): 141-146..
  • Arianne Clare Agdamag, Darshan Krishnappa, David Benditt. ST-Segment Changes After Loss of Consciousness. Circulation. 2020 Jan 7;141(1):80-82.
  • Krishnappa D, Dykoski R, Can I, Mbai M, Anand IS, Florea V, Chandrashekar YS, Li JM, Tholakanahalli VN. Atrial Fibrillation in the Elderly: The Role of Sub-Clinical Isolated Cardiac Amyloidosis. Scientific Reports (Nature) 2019 Nov 12;9(1):16584. PMID:31719596
  • Manojkumar Rohit, Krishnappa D. Incidence and predictors of super-response to cardiac resynchronization therapy. Indian Heart Journal. 2019 Jul - Aug;71(4):334-337.
  • Yash Paul Sharma, Darshan Krishnappa, Kewal Kanabar,Naga Ganesh Kumar Kasinadhuni, Rakesh Sharma, Kamal Kishore,Saurabh Mehrotra, Krishna Santosh Vemuri, Ankur Gupta, Prashant Panda. Clinical Characteristics and Outcome in Patients with a Delayed Presentation after STEMI and Complicated by Cardiogenic Shock. Indian Heart Journal. 2019 Sept – Oct.; 71(5): 387-393.
  • Teerapat Nantsupawat, Darshan Krishnappa, David Benditt. Sinus Arrest: A Rare Observation During Radiofrequency Ablation Along the Coronary Sinus Roof. Annals of Noninvasive Electrocardiography. Article in press
  • Krishnappa D, Sharma SK, Singh AD, Sinha S, Ammini AC, Soneja M. Impact of tuberculosis on glycaemic status: A neglected association. Indian J Med Res. 2019 Mar;149(3):384-388. PMID:31249204
  • Krishnappa D, Scott Sakaguchi, Ganesh Kasinadhuni, Venkatakrishna N Tholakanahalli. An unyielding valve leading to venous spasm during pacemaker implantation: a case report. Eur Heart J Case Rep. Article in press.
  • Vijayvergiya R, Kanabar K, Krishnappa D, Kasinadhuni G, Sharma A, Akasaka T. Optical coherence tomography in varying aetiologies of renal artery stenosis: a case series. Eur Heart J Case Rep. 2019 Jun 1;3(2). PMID: 31449625
  • Krishnappa D, Naganur S, Palanisamy D, Kasinadhuni G. Cardiac mucormycosis: a case report. Eur Heart J Case Rep. 2019 Sep 1;3(3). PMID: 31436824
  • Kasinadhuni G, Vijayvergiya R, Krishnappa D, Kanabar K, Yegurla J and Bhalla. Herb Induced Aconite Poisoning and Bidirectional Ventricular Tachycardia. Adv Clin Toxicol 2019, 4(3): 000161.
  • Kasinadhuni G, Sethi J, Krishnappa D, Sharma YP. A rare cause of ascites in arenal transplant recipient. BMJ Case Rep. 2018 Sep 18;2018. PMID: 30232075
  • Girish B, Gainder S, Saha SC, Krishnappa D. Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. J Obstet Gynaecol India. 2018 Feb;68(1):70-72. PMID: 29391679
  • Rohit M, Krishnappa D, Selvaraj RJ. Wide to narrow complex tachycardia: What is the diagnosis? J Cardiovasc Electrophysiol. 2018 Mar;29(3):487-488. PMID: 29319207
  • Kumar A, Jain DC, Gupta D, Satyanarayana S, Kumar AM, Chadha SS, Wilson N, Nagaraja SB, Shah AN, Naik B, Yoele D, Syed IF, Achanta S, Sharma SK, Soneja M, Krishnappa D, Prakash BC, Ravish S, Ranganath TS, Chauhan MC, Dave PV, Narayanaswamy MV, Suryakanth M, Bhist A, Sinha UC, Dayal R, Tekumalla RR, Nair S, Kumari AK, Subramonianpillai J, Jali MV, Mahishale VK, Hiremath MB, Khanna A, Lohiya S, Chaudhry A, Shaw N, Varadarajan S, Kapur A, Zachariah R, Harries AD. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health. 2013 May;18(5):636-45. PMID: 23458555
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Prashant Panda, Sandeep S. Rana, Ashim Dass. Cardiac myxoma of mitral valve: An uncommon presentation. Indian Heart Journal Cardiovascular Case Reports. May–September 2018;2(2):77-78.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ankush Gupta, Sarbpreet Singh, Ashish Sharma.Primary stenting of occluded innominate vein in a case of dialysis fistula malfunction- a 3.5-years follow-up. Indian Heart Journal Cardiovascular Case Reports. May–September 2018; 2(2):114-116.
  • Rajesh Vijayvergiya, Ganesh Kasinadhuni, Darshan Krishnappa, Ankush Gupta. Assessment of myocardial bridge by fractional flow reserve and optical coherence tomography in acute myocardial infarction. Indian Heart Journal Cardiovascular Case Reports. October-December 2017;1(3):114-116.
  • Rajesh Vijayvergiya, Ankush Gupta, Ganesh Kasinadhuni, Darshan Krishnappa, Prashant Panda. Intravascular ultrasound supported percutaneous coronary intervention of a large diameter right coronary artery. Indian Heart Journal Cardiovascular Case Reports. May-September 2018; 2(2): 106-107.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Ankush Gupta, Prashant Panda, Kumar J. Ratheesh.Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer. Indian Heart Journal Cardiovascular Case Reports. January-April 2018; 2(2):6-8.
  • Faint on standing from sitting or lying down? Know about Postural Hypotension - Dr. Darshan, Consultant – Cardiac Electrophysiology, Manipal Hospitals, Dr. Deepak P, Consultant – Cardiac Electrophysiology, Manipal Ho.Click Here

    Field of Expertise

  • Heart Rhythm device therapy including Defibrillators and resynchronisation therapy and lead extraction
  • Sudden cardiac arrest - prevention and management
  • Complex arrhythmia management including atrial fibrillation and ventricular arrhythmias
  • Arrhythmias in patients with congenital heart disease
  • Inflammatory cardiomyopathy (sarcoidosis) and amyloidosis
  • Syncope
  • Heart failure

    • Fellowship & Membership

  • Heart Rhythm Society
  • Amerian College of Cardiology
  • European Heart Rhythm Association
  • Indian Heart Rhythm Society

    • Languages Spoken

  • Kannada
  • English
  • Hindi
  • Telugu

    • Talks & Publications

  • Krishnappa D, Wang W, Rooney MR, Norby FL, Oldenburg NC, Soliman EZ, Alonso A, O-Uchi J, Dudley SC Jr, Lutsey PL, Chen LY. Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study. Int J Cardiol. 2021 Jun 1;332:70-77. doi: 10.1016/j.ijcard.2021.02.083.
  • Garg PK, Norby FL, Wang W, Krishnappa D, Soliman EZ, Lutsey PL, Selvin E, Ballantyne CM, Alonso A, Chen LY. Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2021 Nov 1;158:45-52.
  • Kohno R, Cannom DS, Olshansky B, Xi SC, Krishnappa D, Adkisson WO, Norby FL, Fedorowski A, Benditt DG. Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association. J Am Heart Assoc. 2021 Sep 7;10(17):e021002
  • Yash Paul Sharma, Kewal Kanabar, Krishna Santosh, Ganesh Kasinadhuni, Darshan Krishnappa. Role of N-terminal pro-B-type natriuretic peptide in the prediction of outcomes in ST-elevation myocardial infarction complicated by cardiogenic shock. Indian Heart Journal. Article in press
  • Hegde A, Masthi R, Krishnappa D. Hyperlocal Postcode Based Crowdsourced Surveillance Systems in the COVID-19 Pandemic Response. Front Public Health. 2020 Jun 9;8:286
  • Abhiram G Ashwathanarayana, Manphool Singhal, Swayamjeet Satapathy, Ashwani Sood, Bhagwant Rai Mittal, Rohit Manoj Kumar, Madan Parmar, Darshan Krishnappa, Nivedita Rana. 18 F-NaF PET uptake characteristics of coronary artery culprit lesions in a cohort of patients of acute coronary syndrome with ST-elevation myocardial infarction and chronic stable angina: A hybrid fluoride PET/CTCA study. J Nucl Cardiol 2020 Jul 27. Online Ahead of print.
  • Kewal Kanabar, Dinakar Bootla, Navjyot Kaur, C.R.Pruthvi, Darshan Krishnappa, Krishna Santosh, Vivek Guleria, Manoj Kumar Rohit. Outcomes of transcatheter closure of patent ductus arteriosus with the off-label use of large occluders (≥16 mm). Indian Heart Journal. March–April 2020; 72(4): 107-112
  • David G. Benditt , J. Gert van Dijk , Darshan Krishnappa , Wayne O. Adkisson and Scott Sakaguchi. Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults. Frontiers in Cardiovascular Medicine. 2020 May.
  • Darshan Krishnappa, Baris Akdemir, Teerapat Nantsupawat, Balaji Krishnan, Ilknur Can, Selcuk Adabag, Jian-Ming Li, Venkatakrishna N.Tholakanahalli. QTc dispersion as a novel marker in identifying patients requiring an epicardial approach for ablation of scar mediated ventricular tachycardia. Indian Pacing and Electrophysiology Journal. July-August 2020; 20(4): 141-146..
  • Arianne Clare Agdamag, Darshan Krishnappa, David Benditt. ST-Segment Changes After Loss of Consciousness. Circulation. 2020 Jan 7;141(1):80-82.
  • Krishnappa D, Dykoski R, Can I, Mbai M, Anand IS, Florea V, Chandrashekar YS, Li JM, Tholakanahalli VN. Atrial Fibrillation in the Elderly: The Role of Sub-Clinical Isolated Cardiac Amyloidosis. Scientific Reports (Nature) 2019 Nov 12;9(1):16584. PMID:31719596
  • Manojkumar Rohit, Krishnappa D. Incidence and predictors of super-response to cardiac resynchronization therapy. Indian Heart Journal. 2019 Jul - Aug;71(4):334-337.
  • Yash Paul Sharma, Darshan Krishnappa, Kewal Kanabar,Naga Ganesh Kumar Kasinadhuni, Rakesh Sharma, Kamal Kishore,Saurabh Mehrotra, Krishna Santosh Vemuri, Ankur Gupta, Prashant Panda. Clinical Characteristics and Outcome in Patients with a Delayed Presentation after STEMI and Complicated by Cardiogenic Shock. Indian Heart Journal. 2019 Sept – Oct.; 71(5): 387-393.
  • Teerapat Nantsupawat, Darshan Krishnappa, David Benditt. Sinus Arrest: A Rare Observation During Radiofrequency Ablation Along the Coronary Sinus Roof. Annals of Noninvasive Electrocardiography. Article in press
  • Krishnappa D, Sharma SK, Singh AD, Sinha S, Ammini AC, Soneja M. Impact of tuberculosis on glycaemic status: A neglected association. Indian J Med Res. 2019 Mar;149(3):384-388. PMID:31249204
  • Krishnappa D, Scott Sakaguchi, Ganesh Kasinadhuni, Venkatakrishna N Tholakanahalli. An unyielding valve leading to venous spasm during pacemaker implantation: a case report. Eur Heart J Case Rep. Article in press.
  • Vijayvergiya R, Kanabar K, Krishnappa D, Kasinadhuni G, Sharma A, Akasaka T. Optical coherence tomography in varying aetiologies of renal artery stenosis: a case series. Eur Heart J Case Rep. 2019 Jun 1;3(2). PMID: 31449625
  • Krishnappa D, Naganur S, Palanisamy D, Kasinadhuni G. Cardiac mucormycosis: a case report. Eur Heart J Case Rep. 2019 Sep 1;3(3). PMID: 31436824
  • Kasinadhuni G, Vijayvergiya R, Krishnappa D, Kanabar K, Yegurla J and Bhalla. Herb Induced Aconite Poisoning and Bidirectional Ventricular Tachycardia. Adv Clin Toxicol 2019, 4(3): 000161.
  • Kasinadhuni G, Sethi J, Krishnappa D, Sharma YP. A rare cause of ascites in arenal transplant recipient. BMJ Case Rep. 2018 Sep 18;2018. PMID: 30232075
  • Girish B, Gainder S, Saha SC, Krishnappa D. Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. J Obstet Gynaecol India. 2018 Feb;68(1):70-72. PMID: 29391679
  • Rohit M, Krishnappa D, Selvaraj RJ. Wide to narrow complex tachycardia: What is the diagnosis? J Cardiovasc Electrophysiol. 2018 Mar;29(3):487-488. PMID: 29319207
  • Kumar A, Jain DC, Gupta D, Satyanarayana S, Kumar AM, Chadha SS, Wilson N, Nagaraja SB, Shah AN, Naik B, Yoele D, Syed IF, Achanta S, Sharma SK, Soneja M, Krishnappa D, Prakash BC, Ravish S, Ranganath TS, Chauhan MC, Dave PV, Narayanaswamy MV, Suryakanth M, Bhist A, Sinha UC, Dayal R, Tekumalla RR, Nair S, Kumari AK, Subramonianpillai J, Jali MV, Mahishale VK, Hiremath MB, Khanna A, Lohiya S, Chaudhry A, Shaw N, Varadarajan S, Kapur A, Zachariah R, Harries AD. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health. 2013 May;18(5):636-45. PMID: 23458555
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Prashant Panda, Sandeep S. Rana, Ashim Dass. Cardiac myxoma of mitral valve: An uncommon presentation. Indian Heart Journal Cardiovascular Case Reports. May–September 2018;2(2):77-78.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ankush Gupta, Sarbpreet Singh, Ashish Sharma.Primary stenting of occluded innominate vein in a case of dialysis fistula malfunction- a 3.5-years follow-up. Indian Heart Journal Cardiovascular Case Reports. May–September 2018; 2(2):114-116.
  • Rajesh Vijayvergiya, Ganesh Kasinadhuni, Darshan Krishnappa, Ankush Gupta. Assessment of myocardial bridge by fractional flow reserve and optical coherence tomography in acute myocardial infarction. Indian Heart Journal Cardiovascular Case Reports. October-December 2017;1(3):114-116.
  • Rajesh Vijayvergiya, Ankush Gupta, Ganesh Kasinadhuni, Darshan Krishnappa, Prashant Panda. Intravascular ultrasound supported percutaneous coronary intervention of a large diameter right coronary artery. Indian Heart Journal Cardiovascular Case Reports. May-September 2018; 2(2): 106-107.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Ankush Gupta, Prashant Panda, Kumar J. Ratheesh.Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer. Indian Heart Journal Cardiovascular Case Reports. January-April 2018; 2(2):6-8.
  • Faint on standing from sitting or lying down? Know about Postural Hypotension - Dr. Darshan, Consultant – Cardiac Electrophysiology, Manipal Hospitals, Dr. Deepak P, Consultant – Cardiac Electrophysiology, Manipal Ho.Click Here

    • Overview

  • Dr. Darshan Krishnappa is an exceptionally accomplished Cardiac Electrophysiologist and Cardiologist at Old Airport Road with over 16+ years of extensive clinical experience in the management of complex cardiac rhythm disorders, advanced catheter ablation, and device-based therapies. He is currently practising as a Lead Consultant – Cardiac Electrophysiology at Manipal Hospital Old Airport Road, Bangalore. Dr. Krishnappa possesses highly specialised expertise in heart rhythm device therapy (including defibrillators and cardiac resynchronisation therapy), complex arrhythmia mapping, sudden cardiac arrest prevention, and lead extractions. His integration of advanced ablation techniques with cutting-edge medical device technology has established him among the best cardiac electrophysiologists in Old Airport Road for precision heart rhythm care.

  • Dr. Krishnappa completed his foundational MBBS at the Kempegowda Institute of Medical Sciences (KIMS), Bengaluru. He then undertook highly competitive postgraduate training in Internal Medicine (MD) at the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi, providing him a rigorous grounding in critical care and complex multisystem diseases. He subsequently pursued super-speciality training in Cardiology (DM) at the leading Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, gaining high-volume exposure to advanced interventional cardiology. To further subspecialise, he completed a Clinical Cardiac Electrophysiology Fellowship at the University of Minnesota, Minneapolis, USA, while simultaneously serving as an Innovation Fellow at the Earl E. Bakken Medical Devices Centre.

  • At Manipal Hospital Old Airport Road, Dr. Darshan Krishnappa performs a broad spectrum of advanced cardiac electrophysiology procedures with an emphasis on physiological precision and long-term rhythm stability. His clinical portfolio features complex arrhythmia management, including specialised catheter ablations for atrial fibrillation (AF) and ventricular arrhythmias. He is highly proficient in handling challenging heart rhythm issues in patients with congenital heart disease, inflammatory cardiomyopathy (sarcoidosis), cardiac amyloidosis, and syncope. (Note: The hospital's portal mistakenly auto-categorised him under a completely separate speciality in one line, but his practice is strictly dedicated to advanced cardiovascular rhythm care.) His clinical mastery positions him among the best heart specialists and cardiologists in Old Airport Road, Bangalore.

  • Dr. Krishnappa’s technical expertise is uniquely augmented by his contributions to translational medicine and biomedical engineering. Further reflecting his leadership in the field, he serves as India’s Representative to the Asia Pacific Heart Rhythm Society (APHRS) EP Committee, actively shaping regional academic collaboration and advancement in cardiac electrophysiology across the Asia-Pacific region. In recognition of his professional excellence and academic contributions, he was elected a Fellow of the American College of Cardiology (FACC).

  • Dr. Darshan Krishnappa is deeply involved in cardiovascular research, boasting an extensive publication record in elite, peer-reviewed global journals such as Circulation, Journal of the American Heart Association, Journal of Cardiovascular Electrophysiology, and Nature Scientific Reports. His landmark research contributions include risk stratification in atrial fibrillation using the ARIC cohort data, substrate characterisation for scar-mediated ventricular tachycardia, and investigating subclinical isolated cardiac amyloidosis in elderly patients. He is an active member of the Heart Rhythm Society (HRS), European Heart Rhythm Association (EHRA), and the Indian Heart Rhythm Society (IHRS). Fluent in Kannada, English, Hindi, and Telugu, he uses his multilingual capabilities to deliver truly personalised, patient-centric care.

    Talks & Publications

  • Krishnappa D, Wang W, Rooney MR, Norby FL, Oldenburg NC, Soliman EZ, Alonso A, O-Uchi J, Dudley SC Jr, Lutsey PL, Chen LY. Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study. Int J Cardiol. 2021 Jun 1;332:70-77. doi: 10.1016/j.ijcard.2021.02.083.
  • Garg PK, Norby FL, Wang W, Krishnappa D, Soliman EZ, Lutsey PL, Selvin E, Ballantyne CM, Alonso A, Chen LY. Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2021 Nov 1;158:45-52.
  • Kohno R, Cannom DS, Olshansky B, Xi SC, Krishnappa D, Adkisson WO, Norby FL, Fedorowski A, Benditt DG. Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association. J Am Heart Assoc. 2021 Sep 7;10(17):e021002
  • Yash Paul Sharma, Kewal Kanabar, Krishna Santosh, Ganesh Kasinadhuni, Darshan Krishnappa. Role of N-terminal pro-B-type natriuretic peptide in the prediction of outcomes in ST-elevation myocardial infarction complicated by cardiogenic shock. Indian Heart Journal. Article in press
  • Hegde A, Masthi R, Krishnappa D. Hyperlocal Postcode Based Crowdsourced Surveillance Systems in the COVID-19 Pandemic Response. Front Public Health. 2020 Jun 9;8:286
  • Abhiram G Ashwathanarayana, Manphool Singhal, Swayamjeet Satapathy, Ashwani Sood, Bhagwant Rai Mittal, Rohit Manoj Kumar, Madan Parmar, Darshan Krishnappa, Nivedita Rana. 18 F-NaF PET uptake characteristics of coronary artery culprit lesions in a cohort of patients of acute coronary syndrome with ST-elevation myocardial infarction and chronic stable angina: A hybrid fluoride PET/CTCA study. J Nucl Cardiol 2020 Jul 27. Online Ahead of print.
  • Kewal Kanabar, Dinakar Bootla, Navjyot Kaur, C.R.Pruthvi, Darshan Krishnappa, Krishna Santosh, Vivek Guleria, Manoj Kumar Rohit. Outcomes of transcatheter closure of patent ductus arteriosus with the off-label use of large occluders (≥16 mm). Indian Heart Journal. March–April 2020; 72(4): 107-112
  • David G. Benditt , J. Gert van Dijk , Darshan Krishnappa , Wayne O. Adkisson and Scott Sakaguchi. Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults. Frontiers in Cardiovascular Medicine. 2020 May.
  • Darshan Krishnappa, Baris Akdemir, Teerapat Nantsupawat, Balaji Krishnan, Ilknur Can, Selcuk Adabag, Jian-Ming Li, Venkatakrishna N.Tholakanahalli. QTc dispersion as a novel marker in identifying patients requiring an epicardial approach for ablation of scar mediated ventricular tachycardia. Indian Pacing and Electrophysiology Journal. July-August 2020; 20(4): 141-146..
  • Arianne Clare Agdamag, Darshan Krishnappa, David Benditt. ST-Segment Changes After Loss of Consciousness. Circulation. 2020 Jan 7;141(1):80-82.
  • Krishnappa D, Dykoski R, Can I, Mbai M, Anand IS, Florea V, Chandrashekar YS, Li JM, Tholakanahalli VN. Atrial Fibrillation in the Elderly: The Role of Sub-Clinical Isolated Cardiac Amyloidosis. Scientific Reports (Nature) 2019 Nov 12;9(1):16584. PMID:31719596
  • Manojkumar Rohit, Krishnappa D. Incidence and predictors of super-response to cardiac resynchronization therapy. Indian Heart Journal. 2019 Jul - Aug;71(4):334-337.
  • Yash Paul Sharma, Darshan Krishnappa, Kewal Kanabar,Naga Ganesh Kumar Kasinadhuni, Rakesh Sharma, Kamal Kishore,Saurabh Mehrotra, Krishna Santosh Vemuri, Ankur Gupta, Prashant Panda. Clinical Characteristics and Outcome in Patients with a Delayed Presentation after STEMI and Complicated by Cardiogenic Shock. Indian Heart Journal. 2019 Sept – Oct.; 71(5): 387-393.
  • Teerapat Nantsupawat, Darshan Krishnappa, David Benditt. Sinus Arrest: A Rare Observation During Radiofrequency Ablation Along the Coronary Sinus Roof. Annals of Noninvasive Electrocardiography. Article in press
  • Krishnappa D, Sharma SK, Singh AD, Sinha S, Ammini AC, Soneja M. Impact of tuberculosis on glycaemic status: A neglected association. Indian J Med Res. 2019 Mar;149(3):384-388. PMID:31249204
  • Krishnappa D, Scott Sakaguchi, Ganesh Kasinadhuni, Venkatakrishna N Tholakanahalli. An unyielding valve leading to venous spasm during pacemaker implantation: a case report. Eur Heart J Case Rep. Article in press.
  • Vijayvergiya R, Kanabar K, Krishnappa D, Kasinadhuni G, Sharma A, Akasaka T. Optical coherence tomography in varying aetiologies of renal artery stenosis: a case series. Eur Heart J Case Rep. 2019 Jun 1;3(2). PMID: 31449625
  • Krishnappa D, Naganur S, Palanisamy D, Kasinadhuni G. Cardiac mucormycosis: a case report. Eur Heart J Case Rep. 2019 Sep 1;3(3). PMID: 31436824
  • Kasinadhuni G, Vijayvergiya R, Krishnappa D, Kanabar K, Yegurla J and Bhalla. Herb Induced Aconite Poisoning and Bidirectional Ventricular Tachycardia. Adv Clin Toxicol 2019, 4(3): 000161.
  • Kasinadhuni G, Sethi J, Krishnappa D, Sharma YP. A rare cause of ascites in arenal transplant recipient. BMJ Case Rep. 2018 Sep 18;2018. PMID: 30232075
  • Girish B, Gainder S, Saha SC, Krishnappa D. Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. J Obstet Gynaecol India. 2018 Feb;68(1):70-72. PMID: 29391679
  • Rohit M, Krishnappa D, Selvaraj RJ. Wide to narrow complex tachycardia: What is the diagnosis? J Cardiovasc Electrophysiol. 2018 Mar;29(3):487-488. PMID: 29319207
  • Kumar A, Jain DC, Gupta D, Satyanarayana S, Kumar AM, Chadha SS, Wilson N, Nagaraja SB, Shah AN, Naik B, Yoele D, Syed IF, Achanta S, Sharma SK, Soneja M, Krishnappa D, Prakash BC, Ravish S, Ranganath TS, Chauhan MC, Dave PV, Narayanaswamy MV, Suryakanth M, Bhist A, Sinha UC, Dayal R, Tekumalla RR, Nair S, Kumari AK, Subramonianpillai J, Jali MV, Mahishale VK, Hiremath MB, Khanna A, Lohiya S, Chaudhry A, Shaw N, Varadarajan S, Kapur A, Zachariah R, Harries AD. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health. 2013 May;18(5):636-45. PMID: 23458555
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Prashant Panda, Sandeep S. Rana, Ashim Dass. Cardiac myxoma of mitral valve: An uncommon presentation. Indian Heart Journal Cardiovascular Case Reports. May–September 2018;2(2):77-78.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ankush Gupta, Sarbpreet Singh, Ashish Sharma.Primary stenting of occluded innominate vein in a case of dialysis fistula malfunction- a 3.5-years follow-up. Indian Heart Journal Cardiovascular Case Reports. May–September 2018; 2(2):114-116.
  • Rajesh Vijayvergiya, Ganesh Kasinadhuni, Darshan Krishnappa, Ankush Gupta. Assessment of myocardial bridge by fractional flow reserve and optical coherence tomography in acute myocardial infarction. Indian Heart Journal Cardiovascular Case Reports. October-December 2017;1(3):114-116.
  • Rajesh Vijayvergiya, Ankush Gupta, Ganesh Kasinadhuni, Darshan Krishnappa, Prashant Panda. Intravascular ultrasound supported percutaneous coronary intervention of a large diameter right coronary artery. Indian Heart Journal Cardiovascular Case Reports. May-September 2018; 2(2): 106-107.
  • Rajesh Vijayvergiya, Darshan Krishnappa, Ganesh Kasinadhuni, Ankush Gupta, Prashant Panda, Kumar J. Ratheesh.Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer. Indian Heart Journal Cardiovascular Case Reports. January-April 2018; 2(2):6-8.
  • Faint on standing from sitting or lying down? Know about Postural Hypotension - Dr. Darshan, Consultant – Cardiac Electrophysiology, Manipal Hospitals, Dr. Deepak P, Consultant – Cardiac Electrophysiology, Manipal Ho.Click Here

    • Overview

  • Dr. Darshan Krishnappa is an exceptionally accomplished Cardiac Electrophysiologist and Cardiologist at Old Airport Road with over 16+ years of extensive clinical experience in the management of complex cardiac rhythm disorders, advanced catheter ablation, and device-based therapies. He is currently practising as a Lead Consultant – Cardiac Electrophysiology at Manipal Hospital Old Airport Road, Bangalore. Dr. Krishnappa possesses highly specialised expertise in heart rhythm device therapy (including defibrillators and cardiac resynchronisation therapy), complex arrhythmia mapping, sudden cardiac arrest prevention, and lead extractions. His integration of advanced ablation techniques with cutting-edge medical device technology has established him among the best cardiac electrophysiologists in Old Airport Road for precision heart rhythm care.

  • Dr. Krishnappa completed his foundational MBBS at the Kempegowda Institute of Medical Sciences (KIMS), Bengaluru. He then undertook highly competitive postgraduate training in Internal Medicine (MD) at the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi, providing him a rigorous grounding in critical care and complex multisystem diseases. He subsequently pursued super-speciality training in Cardiology (DM) at the leading Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, gaining high-volume exposure to advanced interventional cardiology. To further subspecialise, he completed a Clinical Cardiac Electrophysiology Fellowship at the University of Minnesota, Minneapolis, USA, while simultaneously serving as an Innovation Fellow at the Earl E. Bakken Medical Devices Centre.

  • At Manipal Hospital Old Airport Road, Dr. Darshan Krishnappa performs a broad spectrum of advanced cardiac electrophysiology procedures with an emphasis on physiological precision and long-term rhythm stability. His clinical portfolio features complex arrhythmia management, including specialised catheter ablations for atrial fibrillation (AF) and ventricular arrhythmias. He is highly proficient in handling challenging heart rhythm issues in patients with congenital heart disease, inflammatory cardiomyopathy (sarcoidosis), cardiac amyloidosis, and syncope. (Note: The hospital's portal mistakenly auto-categorised him under a completely separate speciality in one line, but his practice is strictly dedicated to advanced cardiovascular rhythm care.) His clinical mastery positions him among the best heart specialists and cardiologists in Old Airport Road, Bangalore.

  • Dr. Krishnappa’s technical expertise is uniquely augmented by his contributions to translational medicine and biomedical engineering. Further reflecting his leadership in the field, he serves as India’s Representative to the Asia Pacific Heart Rhythm Society (APHRS) EP Committee, actively shaping regional academic collaboration and advancement in cardiac electrophysiology across the Asia-Pacific region. In recognition of his professional excellence and academic contributions, he was elected a Fellow of the American College of Cardiology (FACC).

  • Dr. Darshan Krishnappa is deeply involved in cardiovascular research, boasting an extensive publication record in elite, peer-reviewed global journals such as Circulation, Journal of the American Heart Association, Journal of Cardiovascular Electrophysiology, and Nature Scientific Reports. His landmark research contributions include risk stratification in atrial fibrillation using the ARIC cohort data, substrate characterisation for scar-mediated ventricular tachycardia, and investigating subclinical isolated cardiac amyloidosis in elderly patients. He is an active member of the Heart Rhythm Society (HRS), European Heart Rhythm Association (EHRA), and the Indian Heart Rhythm Society (IHRS). Fluent in Kannada, English, Hindi, and Telugu, he uses his multilingual capabilities to deliver truly personalised, patient-centric care.

    • Fellowship & Membership

  • Heart Rhythm Society
  • Amerian College of Cardiology
  • European Heart Rhythm Association
  • Indian Heart Rhythm Society

    • Field of Expertise

  • Heart Rhythm device therapy including Defibrillators and resynchronisation therapy and lead extraction
  • Sudden cardiac arrest - prevention and management
  • Complex arrhythmia management including atrial fibrillation and ventricular arrhythmias
  • Arrhythmias in patients with congenital heart disease
  • Inflammatory cardiomyopathy (sarcoidosis) and amyloidosis
  • Syncope
  • Heart failure

    • Languages Spoken

  • Kannada
  • English
  • Hindi
  • Telugu

FAQ's

Patients visit Dr. Darshan Krishnappa, a leading Lead Consultant - Cardiac Electrophysiologist at Manipal Hospitals Old Airport Road - Bengaluru, for expert care and advanced treatments. Known for accurate diagnoses and patient centric care, Dr. Darshan Krishnappa is a trusted choice for exceptional medical support.

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