Blood cancers are the cancers arising from blood cells, they affect the production and function of normal blood cells namely red blood cells, white blood cells, and platelets.
Blood cancers differ from other cancers arising from solid organs in their origin, symptomatology, diagnosis and treatment.
Following are the common types of blood cancers:
Hodgkin And Non-Hodgkin Lymphoma
Other Rare Types Of Blood Cancers
Blood cancer patients may present with varied clinical manifestations, following are some of the common symptoms of blood cancer:
Generalised Weakness, Fatigue, and Malaise
Bleeding manifestations like easy bruising, Bleeding gums
Unexplained loss of appetite and Weight loss
Sweating of the body during the night
Swellings in the neck, armpit, or other areas due to Lymph node (gland) enlargement
Lumps or underlying abdominal disease due to enlarged abdominal organs
Shortness of breath
Minimal body strain results in bone fractures called as a pathological fracture
If any of the above symptoms are observed such individuals should seek medical advice and undergo evaluation
Following tests may be required to diagnose blood cancers:
Initially, doctors take history and conduct a thorough physical examination of the patient
Blood tests looking at various blood elements called complete blood count with peripheral smear, biochemical evaluations of liver and kidney function tests are initially performed
Many times a special test termed bone marrow examination is done to diagnose blood cancers. It is a simple outpatient test where bone marrow samples are obtained by marrow aspiration and biopsy. Bone marrow is soft, gelatinous tissue that fills the medullary cavities, it contains stem cells that are mother cells forming all formed elements of the blood.
Lymph node or tissue biopsy- Surgical lymph node removal termed excision biopsy, or core biopsies collecting small pieces of the lymph node may be done to establish the diagnosis of the blood cancer
Diagnostic imaging tests like CT scan, PET scan, MRI, and/or x-rays may be performed to assess the extent of the disease at diagnosis, termed pre-treatment staging and later for assessing response after treatment
Treatment for blood cancer depends on many host factors like age of the patient, comorbid illnesses, fitness level, the disease-related factors such as type of blood cancer, the aggressiveness of cancer, and its stage at diagnosis.
Some common blood cancer treatments include:
Chemotherapy: Chemotherapy uses anticancer drugs to stop the growth of cancer cells in the body. Chemotherapy for blood cancer sometimes requires several drugs together in a set regimen. This treatment may also be given before a stem cell transplantation called conditioning chemotherapy.
Blood and Bone marrow transplantation: Haematopoietic stem cell transplantation is one of the intense medical therapies offered for blood cancer patients. The patient is given conditioning therapy followed by an infusion of healthy blood-forming stem cells. Stem cells may be collected from the bone marrow, circulating blood or umbilical cord blood
Following are the common types of bone marrow transplantation:
Autologous Bone Marrow Transplant-transplanted stem cells collected from the patient.
Allogeneic Bone Marrow Transplant-transplanted stem cells are collected from a healthy donor.
Depending on the donor allogeneic transplants are divided into following subtypes:
Matched Related Donor Transplant
Matched Unrelated Donor Transplant
Half-Matched Family Member Donor Transplant
Cord Blood Transplants
Immunotherapy: Immunotherapy sometimes also referred to as biotherapy - uses one’s own immune system to help fight cancer.
It can work directly with the body's immune system to stop or slow the growth of cancer cells. Or, it can indirectly prepare the immune system to destroy or attack cancer cells.
CAR T cell therapy is a type of immunotherapy, here patient’s own T cells – a type of disease-fighting immune cells – are removed and sent to a lab where they are genetically re-engineered to produce chimeric antigen receptors (CARs) on their surface, which can recognise, attack and destroy the cancer cells.
Radiation therapy may sometimes be used with systemic therapy in treating blood cancers, it may be used to destroy cancer cells or to relieve pain or discomfort. It may also be given before a stem cell transplantation as part of conditioning therapy. Radiation therapy uses targeted energy to destroy cancer cells or shrink tumours.
Different chemotherapy has different side-effects.
Fatigue, Nausea, Vomiting, lowering of the blood counts, and hair loss are few of the common adverse effects. Rarely intense chemotherapy may have adverse effects on other organ systems like heart lungs, reproductive organs
Cancer care teams will not only take measures to minimise the adverse events but also address any side effects as they appear during or post-therapy.
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